发明授权
US08486904B2 Antisense modulation of fibroblast growth factor receptor 4 expression
失效
成纤维细胞生长因子受体4表达的反义调控
- 专利标题： Antisense modulation of fibroblast growth factor receptor 4 expression
- 专利标题（中）： 成纤维细胞生长因子受体4表达的反义调控
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申请号： US12681360申请日： 2008-10-01
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公开(公告)号： US08486904B2公开(公告)日： 2013-07-16
- 发明人: Sanjay Bhanot , Xing-Xian Yu , Susan M. Freier , Ravi Jain
- 申请人： Sanjay Bhanot , Xing-Xian Yu , Susan M. Freier , Ravi Jain
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Knobbe, Martens, Olson & Bear, LLP
- 国际申请： PCT/US2008/078497 WO 20081001
- 国际公布： WO2009/046141 WO 20090409
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; C07H21/04
摘要：
Antisense compounds, compositions and methods are provided for modulating the expression of fibroblast growth factor receptor 4 (FGFR4). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding fibroblast growth factor receptor 4. Methods of using these compounds for modulation of fibroblast growth factor receptor 4 expression and for treatment of diseases associated with expression of fibroblast growth factor receptor 4 are provided.
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