发明授权
- 专利标题: Substituted oxindole compounds
- 专利标题(中): 取代的羟吲哚化合物
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申请号: US12529542申请日: 2008-02-29
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公开(公告)号: US08486931B2公开(公告)日: 2013-07-16
- 发明人: Herve Genesle , Thorsten Oost , Charles W. Hutchins , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Astrid Netz , Wolfgang Wernet
- 申请人: Herve Genesle , Thorsten Oost , Charles W. Hutchins , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Astrid Netz , Alfred Hahn
- 申请人地址: DE Wiesbaden
- 专利权人: Abbott GmbH & Co. KG
- 当前专利权人: Abbott GmbH & Co. KG
- 当前专利权人地址: DE Wiesbaden
- 代理机构: Michael Best & Friedrich LLP
- 代理商 Lisa V. Mueller
- 国际申请: PCT/EP2008/052516 WO 20080229
- 国际公布: WO2008/107399 WO 20080912
- 主分类号: A61K31/4439
- IPC分类号: A61K31/4439 ; A61K31/454 ; A61K31/4709 ; A61K31/496 ; A61K31/551
摘要:
The present invention relates to compounds of the general formula (I) in which A, B, R1, R2 and Het have the meaning given in claim 1; Y is a bivalent group of the formula in which D is C1-C3-alkylene, where D may have a substituent R5; R3 is hydrogen, C1-C8-alkyl or together with R4 is C1-C3-alkylene which may have a radical R5a, or together with R5 is C1-C3-alkylene, and R4 is hydrogen, C1-C8-alkyl or together with R3 is C1-C3-alkylene which may have a radical R5a, or together with R5 is C1-C3-alkylene, where R5 together with R5a, where present, are a bond or C1-C3-alkylene; and where one of the following conditions is satisfied: R3 together with R4 is C1-C3-alkylene which may have a radical R5a; or R3 together with R5 is C1-C3-alkylene; or R4 together with R5 is C1-C3-alkylene where the radical A is different from phenyl when the radical B is phenyl or naphthyl; and medicaments which comprise such compounds and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent and/or oxytocin-dependent diseases.
公开/授权文献
- US20100286165A1 SUBSTITUTED OXINDOLE COMPOUNDS 公开/授权日:2010-11-11
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