发明授权
US08487083B2 Monoclonal antibodies capable of simultaneously binding domains II and IIIc of type 1 fibroblast growth factor receptor 有权
能够同时结合1型成纤维细胞生长因子受体的结构域II和IIIc的单克隆抗体

  • 专利标题: Monoclonal antibodies capable of simultaneously binding domains II and IIIc of type 1 fibroblast growth factor receptor
  • 专利标题(中): 能够同时结合1型成纤维细胞生长因子受体的结构域II和IIIc的单克隆抗体
  • 申请号: US13261076
    申请日: 2009-06-30
  • 公开(公告)号: US08487083B2
    公开(公告)日: 2013-07-16
  • 发明人: Ilya Valer'evich Tsimafeyeu
  • 申请人: Ilya Valer'evich Tsimafeyeu
  • 申请人地址: RU Moscow
  • 专利权人: OOO “Oncomax”
  • 当前专利权人: OOO “Oncomax”
  • 当前专利权人地址: RU Moscow
  • 代理商 Aleksandr Smushkovich
  • 国际申请: PCT/EA2009/000004 WO 20090630
  • 国际公布: WO2011/000384 WO 20110106
  • 主分类号: C07K16/00
  • IPC分类号: C07K16/00 C12P21/08
Monoclonal antibodies capable of simultaneously binding domains II and IIIc of type 1 fibroblast growth factor receptor
摘要:
The invention pertains to the field of medicine, particularly to methods for suppressing the growth of tumors, which comprise blocking the pathological pathway of human fibroblast growth factor/receptor 1 (domains II and IIIc), and for diagnosing malignant neoplasms leading to an excessive proliferation of tumor cells and to the formation of new vessels accompanied by the growth of primary tumors and metastases. This pathway also represents an independent mechanism of tumor resistance to preparations acting on other pathological pathways. Blocking the aforementioned pathway using various substances that neutralize the receptor by bonding only with domains II and IIIc thereof results in the interruption or slow-down of tumor growth. This receptor can also be used as a target for delivery of diagnostic agents being largely present in tumor cells. The invention enables developing new agents for diagnosing and treating diseases related to excessive proliferation and neovascularization.
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