Invention Grant
US08487108B2 Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
失效
哌啶基氨基甲酸酯中间体用于合成天冬氨酸蛋白酶抑制剂
- Patent Title: Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
- Patent Title (中): 哌啶基氨基甲酸酯中间体用于合成天冬氨酸蛋白酶抑制剂
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Application No.: US12084928Application Date: 2006-11-13
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Publication No.: US08487108B2Publication Date: 2013-07-16
- Inventor: John J. Baldwin , David A. Claremon , Colin Tice , Salvacion Cacatian , Lawrence W. Dillard , Alexey V. Ishchenko , Jing Yuan , Zhenrong Xu , Gerard McGeehan , Robert D. Simpson , Suresh B. Singh , Wei Zhao , Patrick T. Flaherty
- Applicant: John J. Baldwin , David A. Claremon , Colin Tice , Salvacion Cacatian , Lawrence W. Dillard , Alexey V. Ishchenko , Jing Yuan , Zhenrong Xu , Gerard McGeehan , Robert D. Simpson , Suresh B. Singh , Wei Zhao , Patrick T. Flaherty
- Applicant Address: US PA Fort Washington
- Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee Address: US PA Fort Washington
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- International Application: PCT/US2006/043920 WO 20061113
- International Announcement: WO2007/070201 WO 20070621
- Main IPC: C07D211/22
- IPC: C07D211/22 ; C07D211/60
Abstract:
The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.
Public/Granted literature
- US20100048636A1 Aspartic Protease Inhibitors Public/Granted day:2010-02-25
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