Invention Grant
- Patent Title: Process for the palladium-catalyzed coupling of terminal alkynes with aryl tosylates
- Patent Title (中): 钯催化偶合末端炔烃与芳基甲苯磺酸酯的方法
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Application No.: US12645509Application Date: 2009-12-23
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Publication No.: US08487109B2Publication Date: 2013-07-16
- Inventor: Omar Rkyek , Marc Nazare , Andreas Lindenschmidt , Matthias Urmann , Nis Halland , Jorge Alonso
- Applicant: Omar Rkyek , Marc Nazare , Andreas Lindenschmidt , Matthias Urmann , Nis Halland , Jorge Alonso
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP07290840 20070703
- Main IPC: C07D211/60
- IPC: C07D211/60 ; C07D333/22 ; C07C229/38 ; C07C45/00 ; C07C233/03
Abstract:
The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process for aryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional aryl-1-alkynes of the formula I.
Public/Granted literature
- US20100261910A1 Process for the palladium-catalyzed coupling of terminal alkynes with aryl tosylates Public/Granted day:2010-10-14
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