发明授权
US08487157B2 Transgenic rodents having NGF beta gene mutants and its preparation methods, the preparation methods of the corresponding mutant proteins and the resulting mutant proteins
有权
具有NGFβ基因突变体的转基因啮齿动物及其制备方法，相应的突变蛋白的制备方法和所得的突变蛋白
- 专利标题： Transgenic rodents having NGF beta gene mutants and its preparation methods, the preparation methods of the corresponding mutant proteins and the resulting mutant proteins
- 专利标题（中）： 具有NGFβ基因突变体的转基因啮齿动物及其制备方法，相应的突变蛋白的制备方法和所得的突变蛋白
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申请号： US12812731申请日： 2008-03-07
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公开(公告)号： US08487157B2公开(公告)日： 2013-07-16
- 发明人: Zhiwen Zhou , Hongshan Zhang , Hongbo Chen
- 申请人： Zhiwen Zhou , Hongshan Zhang , Hongbo Chen
- 申请人地址： CN Beijing
- 专利权人： Staidson (Beijing) Pharmaceutical Co., Ltd.
- 当前专利权人： Staidson (Beijing) Pharmaceutical Co., Ltd.
- 当前专利权人地址： CN Beijing
- 代理机构： Sughrue Mion, PLLC
- 优先权： CN200710086017 20070307
- 国际申请： PCT/CN2008/070438 WO 20080307
- 国际公布： WO2008/106896 WO 20080912
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; A01K67/033
摘要：
Transgenic rodents having NGF beta gene mutants in their genomes express NGF beta mutant proteins. The preparation methods of the transgenic rodents, the methods of utilizing the transgenic animals to prepare NGF beta mutant proteins and the resulting NGF beta mutant proteins are provided. The transgenic rodents are useful in preparing human NGF and in the study of the functions of NGF beta mutants and their receptors in the whole animal level, and also useful for screening and purifying NGF beta mutants which have high activity and high security.
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