发明授权
- 专利标题： Methods for detection and quantification of analytes in complex mixtures
- 专利标题（中）： 复杂混合物中分析物的检测和定量方法
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申请号： US13027493申请日： 2011-02-15
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公开(公告)号： US08492094B2公开(公告)日： 2013-07-23
- 发明人: Krassen Dimitrov , Dwayne L. Dunaway
- 申请人： Krassen Dimitrov , Dwayne L. Dunaway
- 申请人地址： US WA Seattle
- 专利权人： The Institute for Systems Biology
- 当前专利权人： The Institute for Systems Biology
- 当前专利权人地址： US WA Seattle
- 代理机构： Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- 代理商 Ivor R. Elrifi; Matthew Pavao
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07H21/04
摘要：
The invention provides a method of detecting a nucleic acid analyte. The method consists of (a) contacting a mixture of nucleic acid analytes under conditions sufficient for hybridization with a plurality of target specific nucleic acid probes each having a different specifier; (b) contacting the mixture under conditions sufficient for hybridization with a corresponding plurality of antigenedigits each having a unique label, the plurality of anti-genedigits having a diversity sufficient to uniquely hybridize to genedigits within the specifiers, and (c) uniquely detecting a hybridized complex between one or more analytes in the mixture, a target specific probe, and an anti-genedigit.