发明授权
- 专利标题: Synthesis of locked nucleic acid derivatives
- 专利标题(中): 锁定核酸衍生物的合成
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申请号: US13336303申请日: 2011-12-23
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公开(公告)号: US08492390B2公开(公告)日: 2013-07-23
- 发明人: Mads Detlef Sorensen , Jesper Wengel , Troels Koch , Signe M. Christensen , Christoph Rosenbohm , Daniel Sejer Pedersen
- 申请人: Mads Detlef Sorensen , Jesper Wengel , Troels Koch , Signe M. Christensen , Christoph Rosenbohm , Daniel Sejer Pedersen
- 申请人地址: DK Hoersholm
- 专利权人: Santaris Pharma A/S
- 当前专利权人: Santaris Pharma A/S
- 当前专利权人地址: DK Hoersholm
- 代理机构: Fish & Richardson P.C.
- 主分类号: C07D473/06
- IPC分类号: C07D473/06 ; C07D473/16 ; C07D473/18 ; C07D473/34 ; C07D473/40 ; C07D239/70 ; C07D239/52 ; A61P31/22
摘要:
The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues.
公开/授权文献
- US20120165514A1 SYNTHESIS OF LOCKED NUCLEIC ACID DERIVATIVES 公开/授权日:2012-06-28