发明授权
- 专利标题： Alkoxy tetrahydro-pyridopyrimidine PDE10 inhibitors
- 专利标题（中）： 烷氧基四氢 - 吡啶并嘧啶PDE10抑制剂
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申请号： US13320038申请日： 2010-05-24
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公开(公告)号： US08492392B2公开(公告)日： 2013-07-23
- 发明人: Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Izzat T. Raheem , John D. Schreier
- 申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Izzat T. Raheem , John D. Schreier
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Sylvia A. Ayler; Gerard M. Devlin
- 国际申请： PCT/US2010/035894 WO 20100524
- 国际公布： WO2010/138430 WO 20101202
- 主分类号： A61K31/519
- IPC分类号： A61K31/519
摘要：
The present invention is directed to alkoxy tetrahydro-pyridopyrimidine compounds of formula I, which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
公开/授权文献
- US20120065211A1 ALKOXY TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS 公开/授权日：2012-03-15
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