Invention Grant
- Patent Title: Process for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses
- Patent Title (中): 制备羟吲哚和邻位取代苯胺的方法及其作为合成中间体的用途
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Application No.: US12769302Application Date: 2010-04-28
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Publication No.: US08492590B2Publication Date: 2013-07-23
- Inventor: Mark James Ford , Gunter Karig
- Applicant: Mark James Ford , Gunter Karig
- Applicant Address: DE Monheim
- Assignee: Bayer CropScience AG
- Current Assignee: Bayer CropScience AG
- Current Assignee Address: DE Monheim
- Agency: Baker Donelson Bearman Caldwell & Berkowitz, PC
- Priority: EP09006050 20090502
- Main IPC: C07C321/14
- IPC: C07C321/14
Abstract:
The present invention relates to processes for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses. The invention further relates to a process for the preparation of compounds of formula (4): where a mixture of an aniline (compound of formula Q) is reacted with a thioether (compound of formula W): in the presence of a chlorinating agent and an organic solvent at a reaction temperature in the range above −65° C. In a subsequent process, this compound is further reacted in the presence of an acid catalyst to give the indole of formula (7) or the oxindole of formula (8):
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