Invention Grant
US08492610B1 Transgeneic animal expressing a multiple mutated form of presenilin 1
有权
表达多发性突变型早老素的转基因动物1
- Patent Title: Transgeneic animal expressing a multiple mutated form of presenilin 1
- Patent Title (中): 表达多发性突变型早老素的转基因动物1
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Application No.: US10088139Application Date: 2000-09-22
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Publication No.: US08492610B1Publication Date: 2013-07-23
- Inventor: Anne Eckert , Walter Muller , Christian Czech , Laurent Pradier , Gunter Tremp
- Applicant: Anne Eckert , Walter Muller , Christian Czech , Laurent Pradier , Gunter Tremp
- Applicant Address: FR Antony
- Assignee: Aventis Pharma S.A.
- Current Assignee: Aventis Pharma S.A.
- Current Assignee Address: FR Antony
- Agency: Lathrop & Gage LLP
- Priority: FR9912017 19990927
- International Application: PCT/FR00/02623 WO 20000922
- International Announcement: WO01/22811 WO 20010405
- Main IPC: G01N33/00
- IPC: G01N33/00 ; A01K67/00 ; A01K67/27 ; C12N5/07
Abstract:
The present invention relates to the field of transgenic animal models and more particularly the animal models of Alzheimer's disease. The invention relates to a transgenic animal expressing a multimutated form of presenilin 1 and allowing an apoptotic phenomenon to be detected in a renewable peripheral tissue.
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