A system for clamping a flexible tube containing medical fluids includes a cable assembly coupled to a remote driver and a slidable clamp that imparts a clamping force to the flexible tube. An electrical continuity detector is included to measure the wear of an internal insulating layer of the cable between a sliding inner wire and a cable casing member. An indication of the wear to the cable is generated in response to a comparison of the electrical integrity of the insulating layer with a threshold. The wear indication enables the cable to be repaired or replaced prior to a malfunction of the overall tube clamp system.