发明授权
- 专利标题： Process for the preparation of beta-lactam compounds
- 专利标题（中）： 制备β-内酰胺化合物的方法
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申请号： US12528695申请日： 2008-03-10
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公开(公告)号： US08497088B2公开(公告)日： 2013-07-30
- 发明人: Thomas Van Der Does , Harold Monro Moody , Theodorus Johannes Godfried Maria Van Dooren
- 申请人： Thomas Van Der Does , Harold Monro Moody , Theodorus Johannes Godfried Maria Van Dooren
- 申请人地址： NL Delft
- 专利权人： DSM Sinochem Pharmaceuticals Netherlands B.V.
- 当前专利权人： DSM Sinochem Pharmaceuticals Netherlands B.V.
- 当前专利权人地址： NL Delft
- 代理机构： Nixon & Vanderhye P.C.
- 优先权： EP07103850 20070309
- 国际申请： PCT/EP2008/052809 WO 20080310
- 国际公布： WO2008/110527 WO 20080918
- 主分类号： C12P1/00
- IPC分类号： C12P1/00
摘要：
The present invention describes a process for the synthesis of a semi-synthetic β-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side chain ester and an enzyme catalyzing the coupling of the side chain ester to the nucleus characterized in that the side chain ester is not isolated as a solid intermediate.
公开/授权文献
- US20110104748A1 PROCESS FOR THE PREPARATION OF BETA-LACTAM COMPOUNDS 公开/授权日：2011-05-05
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