发明授权
US08497281B2 Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
有权
六氢茚基吡啶和八氢苯并喹啉的芳基和杂芳基羰基衍生物
- 专利标题： Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
- 专利标题（中）： 六氢茚基吡啶和八氢苯并喹啉的芳基和杂芳基羰基衍生物
-
申请号： US12940387申请日： 2010-11-05
-
公开(公告)号： US08497281B2公开(公告)日： 2013-07-30
- 发明人: Matthias Eckhardt , Stefan Peters , Herbert Nar , Frank Himmelsbach , Linghang Zhuang
- 申请人： Matthias Eckhardt , Stefan Peters , Herbert Nar , Frank Himmelsbach , Linghang Zhuang
- 申请人地址： US PA Fort Washington DE Ingelheim am Rhein
- 专利权人： Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- 当前专利权人： Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- 当前专利权人地址： US PA Fort Washington DE Ingelheim am Rhein
- 代理机构： McCarter & English, LLP
- 代理商 Steven G. Davis; Michael J. DeGrazia
- 优先权： EP09175233 20091106
- 主分类号： C07D401/06
- IPC分类号： C07D401/06 ; A61K31/352
摘要：
The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
公开/授权文献
信息查询
