An open phase detection system and method for a three-phase motor is provided. The open phase detection system comprises: a signal generating unit coupled to the three-phase motor and configured to generate a driving signal for driving the three-phase motor; a detecting unit coupled to the signal generating unit, and configured to detect whether the signal generating unit generates the driving signal and to detect three-phase current values of the three-phase motor; and a determining unit coupled to the detecting unit, and configured to determine whether the three-phase motor has open phase according to the three phase current values detected by the detecting unit when the driving signal is detected.