A method of transmitting packet in a mobile station is provided. The method includes determining whether a resource reserved for a special purpose is overlapped with a resource for transmitting a packet by the mobile station, on the basis of resource allocation information on the mobile station, and delaying the transmission of the packet if the reserved resource is overlapped with the resource for transmitting the packet. Accordingly, it is possible to increase uplink packet transmission efficiency without increasing downlink overhead, by avoiding or adjusting collision of an uplink packet transmission with a time-frequency resource reserved for another purpose.