发明授权
US08501178B2 Use of DR6 and p75 antagonists to promote survival of cells of the nervous system
失效
使用DR6和p75拮抗剂促进神经系统细胞的存活
- 专利标题: Use of DR6 and p75 antagonists to promote survival of cells of the nervous system
- 专利标题(中): 使用DR6和p75拮抗剂促进神经系统细胞的存活
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申请号: US13131231申请日: 2009-11-24
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公开(公告)号: US08501178B2公开(公告)日: 2013-08-06
- 发明人: Sha Mi , Kenneth J. Rhodes , R. Blake Pepinsky
- 申请人: Sha Mi , Kenneth J. Rhodes , R. Blake Pepinsky
- 申请人地址: US MA Cambridge
- 专利权人: Biogen Idec MA Inc.
- 当前专利权人: Biogen Idec MA Inc.
- 当前专利权人地址: US MA Cambridge
- 代理机构: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 国际申请: PCT/US2009/065755 WO 20091124
- 国际公布: WO2010/062904 WO 20100603
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; A61K39/395
摘要:
The present invention relates to Death Receptor-6 (DR6) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to be important for regulating apoptosis in cells of the nervous system. In addition, it has been discovered that p75 is a ligand for DR6. As a result, this invention relates to methods for inhibiting the interaction of DR6 and p75 using DR6 and/or p75 antagonists. In addition, the methods described herein include methods of promoting survival of cells of the nervous system using DR6 antagonists, optionally in combination with p75 antagonists, and methods of treating neurodegenerative conditions by the administration of a DR6 antagonists, optionally in combination with a p75 antagonist.