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US08501438B2 Production of glycoproteins with reduced O-glycosylation 有权
生产具有降低的O-糖基化的糖蛋白

Production of glycoproteins with reduced O-glycosylation
Abstract:
A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.
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