Invention Grant
US08501488B2 Compound for derivatizing polypeptides and method for sequencing and quantifying amino acids in polypeptides using the same
有权
用于衍生多肽的化合物和使用其进行多肽中的氨基酸测序和定量的方法
- Patent Title: Compound for derivatizing polypeptides and method for sequencing and quantifying amino acids in polypeptides using the same
- Patent Title (中): 用于衍生多肽的化合物和使用其进行多肽中的氨基酸测序和定量的方法
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Application No.: US11630625Application Date: 2005-06-29
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Publication No.: US08501488B2Publication Date: 2013-08-06
- Inventor: Sang-Won Lee , Yong-Ho Lee
- Applicant: Sang-Won Lee , Yong-Ho Lee
- Applicant Address: KR Seoul
- Assignee: Korea University Industry and Academy Cooperation Foundation
- Current Assignee: Korea University Industry and Academy Cooperation Foundation
- Current Assignee Address: KR Seoul
- Agency: Christie, Parker & Hale, LLP
- Priority: KR10-2004-0050751 20040630
- International Application: PCT/KR2005/002044 WO 20050629
- International Announcement: WO2006/004341 WO 20060112
- Main IPC: C07C331/28
- IPC: C07C331/28 ; G01N33/00
Abstract:
The present invention relates to a compound for N-terminal substitution of polypeptides which is used in sequencing and quantifying amino acids and a method for sequencing and quantifying an amino acid sequence using the same. The method for sequencing and quantifying amino acids in accordance with the present invention leads to a relative quantitative analysis of proteins with very high reliability, and can distinctively discriminate between y-type ions and b-type ions on the MS/MS spectra, providing the means for realization of high-reliability protein identification.
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