发明授权
US08501933B2 Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists
有权
噻唑和恶唑取代的芳基酰胺作为P2X3和P2X2 / 3拮抗剂
- 专利标题： Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists
- 专利标题（中）： 噻唑和恶唑取代的芳基酰胺作为P2X3和P2X2 / 3拮抗剂
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申请号： US12843563申请日： 2010-07-26
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公开(公告)号： US08501933B2公开(公告)日： 2013-08-06
- 发明人: Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
- 申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
- 申请人地址： US CA Palo Alto
- 专利权人： Roche Palo Alto LLC
- 当前专利权人： Roche Palo Alto LLC
- 当前专利权人地址： US CA Palo Alto
- 代理商 Robert C. Hall
- 主分类号： C07D345/00
- IPC分类号： C07D345/00 ; C07D517/00
摘要：
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is a group of formula A or formula B, and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.
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