The present invention relates to a method of transmitting a multi-carrier signal intended to be used by a system with Nt transmit antennas, where Nt is greater than or equal to two, and Nr receive antennas, where Nr is greater than or equal to one, of the type using OFDM/OQAM modulation and distributing symbols before transmission in a time-frequency plane, in which method the symbols are distributed over blocks of particular size nt.nf where nt≧3 and nf≧3. The method comprises real type space-time block coding by a space-time coder of blocks using a coding matrix of particular size Nt×N and of particular efficiency Nc/N to generate Nt coded sequences of N blocks of symbols of an input sequence of Nc blocks of symbols.