A system includes a light source, a photodetector in optical communication with the light source, and a processor in communication with said photodetector and configured to output a signal representing oxygen saturation independent of an interfering signal from an interfering source. The system may further include an analog-to-digital converter in communication with the processor that is configured to digitize a signal from the photodetector by oversampling and output oversampling data to the processor. The processor may include an averaging filter that averages the oversampling data received from said analog-to-digital converter prior to decimation to generate an oversampling number.