发明授权
- 专利标题: Compounds having affinity for amyloid
- 专利标题(中): 对淀粉样蛋白具有亲和性的化合物
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申请号: US13537422申请日: 2012-06-29
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公开(公告)号: US08506930B2公开(公告)日: 2013-08-13
- 发明人: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- 申请人: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- 申请人地址: JP Tokyo
- 专利权人: Nihon Medi-Physics Co., Ltd.
- 当前专利权人: Nihon Medi-Physics Co., Ltd.
- 当前专利权人地址: JP Tokyo
- 代理机构: Fitch, Even, Tabin & Flannery, LLP
- 优先权: JP2006-140044 20060519; JP2006-324701 20061130
- 主分类号: A61K51/00
- IPC分类号: A61K51/00 ; A61M36/14
摘要:
The present invention provides a compound which has affinity with amyloid, shows sufficiently rapid clearance from normal tissues and is suppressed in toxicity such as mutagencity. Provided is a compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represents a carbon or nitrogen; R1 is a halogen substituent; R2 is a halogen substituent; and m is an integer of 0 to 2, provided that at least one of R1 and R2 is a radioactive halogen substituent, at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4 as well as a low-toxic diagnostic agent comprising a compound represented by the preceding formula or a salt thereof.
公开/授权文献
- US20120271053A1 NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID 公开/授权日:2012-10-25
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