Invention Grant
- Patent Title: Enhanced protein production in Bacillus
- Patent Title (中): 增强芽孢杆菌中的蛋白质生产
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Application No.: US12743187Application Date: 2008-12-19
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Publication No.: US08512982B2Publication Date: 2013-08-20
- Inventor: Marguerite A. Cervin , Eugenio Ferrari , Scott D. Power
- Applicant: Marguerite A. Cervin , Eugenio Ferrari , Scott D. Power
- Applicant Address: US CA Palo Alto
- Assignee: Danisco US Inc.
- Current Assignee: Danisco US Inc.
- Current Assignee Address: US CA Palo Alto
- Agency: Danisco US Inc.
- International Application: PCT/US2008/087633 WO 20081219
- International Announcement: WO2009/094084 WO 20090730
- Main IPC: C12P21/02
- IPC: C12P21/02 ; C12N15/63 ; C07H21/04

Abstract:
The present invention relates to cells that have been genetically manipulated to have an altered capacity to express and/or produce proteins of interest. In particular, the present invention relates to modified host cells of Gram-positive microorganisms, such as Bacillus species that are capable of overexpressing ymaH. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode YmaH, and the modified host cells comprising them. In particular, the present invention relates to compositions and methods of overexpressing YmaH for enhancing the expression and production of proteins of interest (e.g., proteases) in Bacillus species.
Public/Granted literature
- US20110117598A1 Enhanced Protein Production in Bacillus Public/Granted day:2011-05-19
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