发明授权
US08513237B2 Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
有权
磺酰氨基衍生物作为组蛋白脱乙酰酶的新型抑制剂
- 专利标题： Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
- 专利标题（中）： 磺酰氨基衍生物作为组蛋白脱乙酰酶的新型抑制剂
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申请号： US13425690申请日： 2012-03-21
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公开(公告)号： US08513237B2公开(公告)日： 2013-08-20
- 发明人: Kristof Van Emelen , Leo Jacobus Jozel Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
- 申请人： Kristof Van Emelen , Leo Jacobus Jozel Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van heusden
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人地址： BE Beerse
- 代理机构： Woodcock Washburn LLP
- 优先权： WOPCT/EP02/14481 20021218
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; A61K31/506 ; A61K31/4545 ; A61K31/5377 ; C07D211/58 ; C07D401/04 ; C07D401/14 ; C07D413/14
摘要：
This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.