发明授权
- 专利标题： Activatable binding polypeptides and methods of identification and use thereof
- 专利标题（中）： 可活化的结合多肽及其鉴定和使用的方法
-
申请号： US13411409申请日： 2012-03-02
-
公开(公告)号： US08518404B2公开(公告)日： 2013-08-27
- 发明人: Patrick Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare , Jason Sagert
- 申请人： Patrick Daugherty , Nancy Stagliano , Jerry Thomas , Kathryn Kamath , James W. West , Sanjay Khare , Jason Sagert
- 申请人地址： US CA Oakland US CA South San Francisco
- 专利权人： The Regents of the University of California,CytomX Therapeutics, Inc.
- 当前专利权人： The Regents of the University of California,CytomX Therapeutics, Inc.
- 当前专利权人地址： US CA Oakland US CA South San Francisco
- 代理机构： Bozicevic, Field & Francis LLP
- 代理商 Michael B. Rubin
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395 ; C07K16/28 ; C07K16/46
摘要：
Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
公开/授权文献
信息查询
