Invention Grant
- Patent Title: Spiro-oxindole MDM2 antagonists
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Application No.: US12945511Application Date: 2010-11-12
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Publication No.: US08518984B2Publication Date: 2013-08-27
- Inventor: Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
- Applicant: Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones SC
- Main IPC: C07D487/10
- IPC: C07D487/10 ; A61K31/4015
Abstract:
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
Public/Granted literature
- US20110112052A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS Public/Granted day:2011-05-12
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