发明授权
- 专利标题： Compositions and methods for modification of biomolecules
- 专利标题（中）： 用于修饰生物分子的组合物和方法
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申请号： US13024908申请日： 2011-02-10
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公开(公告)号： US08519122B2公开(公告)日： 2013-08-27
- 发明人: John C. Jewett , Carolyn Ruth Bertozzi , Ellen May Sletten , Chelsea Gloria Gordon
- 申请人： John C. Jewett , Carolyn Ruth Bertozzi , Ellen May Sletten , Chelsea Gloria Gordon
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： Bozicevic, Field & Francis LLP.
- 代理商 Paula A. Borden; Rudy J. Ng
- 主分类号： C07D225/04
- IPC分类号： C07D225/04
摘要：
Provided are modified cycloalkyne compounds; and methods of use of such compounds in modifying biomolecules. Embodiments include a cycloaddition reaction that can be carried out under physiological conditions. The cycloaddition reaction involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo and in vitro.
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