发明授权
US08524737B2 Bi- and polycyclic substituted isoquinoline and isoquinolinone derivatives
有权
双环和多环取代的异喹啉和异喹啉酮衍生物
- 专利标题： Bi- and polycyclic substituted isoquinoline and isoquinolinone derivatives
- 专利标题（中）： 双环和多环取代的异喹啉和异喹啉酮衍生物
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申请号： US13000202申请日： 2009-06-18
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公开(公告)号： US08524737B2公开(公告)日： 2013-09-03
- 发明人: Oliver Plettenburg , Katrin Lorenz , Matthias Loehn , Olivier Duclos , Sandrine Biscarrat
- 申请人： Oliver Plettenburg , Katrin Lorenz , Matthias Loehn , Olivier Duclos , Sandrine Biscarrat
- 申请人地址： FR Paris
- 专利权人： Sanofi
- 当前专利权人： Sanofi
- 当前专利权人地址： FR Paris
- 代理机构： Scully, Scott, Murphy & Presser, P.C.
- 优先权： EP08290607 20080624
- 国际申请： PCT/EP2009/004393 WO 20090618
- 国际公布： WO2009/156092 WO 20091230
- 主分类号： C07D495/08
- IPC分类号： C07D495/08 ; C07D217/24 ; A61K31/47
摘要：
The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.