An interface with universal serial communication comprises a switching device, a medium device, and a data restoring device for transmitting the data and obtaining the serial communication via one signal line that is inter-strung by afore devices. By simplifying such communication device, the compatibility thereof could be enhanced. Moreover, during the data transmission, computation made by an error coefficient and an error beyond value in the switching device allows the transmitted data to be kept within an acceptable noise value, so that the accuracy of the data could be assured.