发明授权
- 专利标题: Human monoclonal antibodies against CD20
- 专利标题(中): 针对CD20的人单克隆抗体
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申请号: US10687799申请日: 2003-10-17
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公开(公告)号: US08529902B2公开(公告)日: 2013-09-10
- 发明人: Jessica Teeling , Sigrid Ruuls , Martin Glennie , Jan G. J. van de Winkel , Paul Parren , Jørgen Petersen , Ole Baadsgaard , Haichun Huang
- 申请人: Jessica Teeling , Sigrid Ruuls , Martin Glennie , Jan G. J. van de Winkel , Paul Parren , Jørgen Petersen , Ole Baadsgaard , Haichun Huang
- 申请人地址: DK Copenhagen
- 专利权人: Genmab A/S
- 当前专利权人: Genmab A/S
- 当前专利权人地址: DK Copenhagen
- 代理机构: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 主分类号: C07K16/18
- IPC分类号: C07K16/18 ; C07K16/28 ; C07K16/30 ; A61K39/395 ; C12N5/12
摘要:
Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
公开/授权文献
- US20040167319A1 Human monoclonal antibodies against CD20 公开/授权日:2004-08-26