Invention Grant
- Patent Title: Human monoclonal antibodies against CD20
- Patent Title (中): 针对CD20的人单克隆抗体
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Application No.: US10687799Application Date: 2003-10-17
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Publication No.: US08529902B2Publication Date: 2013-09-10
- Inventor: Jessica Teeling , Sigrid Ruuls , Martin Glennie , Jan G. J. van de Winkel , Paul Parren , Jørgen Petersen , Ole Baadsgaard , Haichun Huang
- Applicant: Jessica Teeling , Sigrid Ruuls , Martin Glennie , Jan G. J. van de Winkel , Paul Parren , Jørgen Petersen , Ole Baadsgaard , Haichun Huang
- Applicant Address: DK Copenhagen
- Assignee: Genmab A/S
- Current Assignee: Genmab A/S
- Current Assignee Address: DK Copenhagen
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Main IPC: C07K16/18
- IPC: C07K16/18 ; C07K16/28 ; C07K16/30 ; A61K39/395 ; C12N5/12

Abstract:
Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Public/Granted literature
- US20040167319A1 Human monoclonal antibodies against CD20 Public/Granted day:2004-08-26
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