Invention Grant
US08530155B2 Methods for diagnosis of common acute lymphoblastic leukemia by determining the level of gene expression
失效
通过确定基因表达水平诊断常见急性淋巴细胞白血病的方法
- Patent Title: Methods for diagnosis of common acute lymphoblastic leukemia by determining the level of gene expression
- Patent Title (中): 通过确定基因表达水平诊断常见急性淋巴细胞白血病的方法
-
Application No.: US12377863Application Date: 2007-08-17
-
Publication No.: US08530155B2Publication Date: 2013-09-10
- Inventor: Stefan Burdach , Günther Richter
- Applicant: Stefan Burdach , Günther Richter
- Applicant Address: DE Munich
- Assignee: Stefan Burdach
- Current Assignee: Stefan Burdach
- Current Assignee Address: DE Munich
- Agency: Smith Patent Consulting
- Agent Chalin A. Smith
- Priority: EP06017264 20060818
- International Application: PCT/EP2007/007297 WO 20070817
- International Announcement: WO2008/019872 WO 20080221
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The present invention refers to a method and a kit for diagnosing pediatric common acute leukemia by distinguishing between normal and common acute lymphoblastic leukemic (cALL) cells, wherein the method comprises the step of determining the gene expression of specific genes (markers) referring to this disease and the step of determining whether these genes are up-regulated or down-regulated. The method for determining the gene expression levels can apply hybridization techniques or PCR methods or combinations thereof. The present invention provides new gene markers, which have not been reported in context with cALL and are suitable for the diagnosis of this disease. In addition, the present invention refers to utilizing these targets for the development of targeted therapies employing RNA- and DNA-interference, antibodies, aptamers, anticalins and other small molecules.
Public/Granted literature
Information query
