发明授权
- 专利标题： Inhibitors of AKT activity
- 专利标题（中）： AKT活性抑制剂
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申请号： US12995892申请日： 2009-05-27
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公开(公告)号： US08536193B2公开(公告)日： 2013-09-17
- 发明人: Hidetomo Furuyama , Yasuhiro Goto , Nobuhiko Kawanishi , Mark E. Layton , Takashi Mita , Yoshio Ogino , Yu Onozaki , Michael A. Rossi , Toshihiro Sakamoto , Philip E. Sanderson , Jiabing Wang
- 申请人： Hidetomo Furuyama , Yasuhiro Goto , Nobuhiko Kawanishi , Mark E. Layton , Takashi Mita , Yoshio Ogino , Yu Onozaki , Michael A. Rossi , Toshihiro Sakamoto , Philip E. Sanderson , Jiabing Wang
- 申请人地址： US NJ Rahway JP Chiyoda-Ku, Tokyo
- 专利权人： Merck Sharp & Dohme Corp.,MSD K.K.
- 当前专利权人： Merck Sharp & Dohme Corp.,MSD K.K.
- 当前专利权人地址： US NJ Rahway JP Chiyoda-Ku, Tokyo
- 代理商 Yong Zhao; David A. Muthard; Matthew A. Leff
- 国际申请： PCT/US2009/045213 WO 20090527
- 国际公布： WO2009/148887 WO 20091210
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61K31/4375 ; C07D471/16
摘要：
The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity, especially Akt1 by administering the compound to a patient in need of treatment of cancer.
公开/授权文献
- US20110082135A1 INHIBITORS OF AKT ACTIVITY 公开/授权日：2011-04-07
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