发明授权
- 专利标题： Process for making substituted 2-amino-thiazolones
- 专利标题（中）： 制备取代的2-氨基 - 噻唑酮的方法
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申请号： US12999961申请日： 2009-06-16
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公开(公告)号： US08536345B2公开(公告)日： 2013-09-17
- 发明人: George A. Moniz , Matthew J. Frizzle , Charles Bernard , Michael Martinelli , Margaret Faul , Jay Larrow , Karl B. Hansen , Liane Klingensmith
- 申请人： George A. Moniz , Matthew J. Frizzle , Charles Bernard , Michael Martinelli , Margaret Faul , Jay Larrow , Karl B. Hansen , Liane Klingensmith
- 申请人地址： US CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： US CA Thousand Oaks
- 代理机构： Foley & Lardner LLP
- 国际申请： PCT/US2009/047469 WO 20090616
- 国际公布： WO2010/008729 WO 20100121
- 主分类号： C07D277/54
- IPC分类号： C07D277/54
摘要：
The present invention relates to methods of making compounds that inhibit 11-β-hydroxysteroid dehydrogenase type 1 enzyme (11-β HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I); wherein Z, R1, R2, and R3 are defined herein.
公开/授权文献
- US20110160463A1 PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES 公开/授权日：2011-06-30
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