发明授权
US08536361B2 1,4,6,10-tetra-double bond pentadec-carbon phosphonate, preparation method thereof, and preparation method of lycopene using the same
有权
1,4,6,10-四 - 双键十五碳酸膦酸酯，其制备方法以及使用其的番茄红素的制备方法
- 专利标题： 1,4,6,10-tetra-double bond pentadec-carbon phosphonate, preparation method thereof, and preparation method of lycopene using the same
- 专利标题（中）： 1,4,6,10-四 - 双键十五碳酸膦酸酯，其制备方法以及使用其的番茄红素的制备方法
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申请号： US13576659申请日： 2011-01-30
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公开(公告)号： US08536361B2公开(公告)日： 2013-09-17
- 发明人: Runpu Shen , Weidong Ye , Shiqing Pi , Xuejun Lao , Luo Liu , Xiaohua Song , Chunlei Wu , Zhigang Wu
- 申请人： Runpu Shen , Weidong Ye , Shiqing Pi , Xuejun Lao , Luo Liu , Xiaohua Song , Chunlei Wu , Zhigang Wu
- 代理机构： Lipton, Weinberger & Husick
- 代理商 Ash Tankha
- 优先权： CN201010104281 20100202
- 国际申请： PCT/CN2011/000157 WO 20110130
- 国际公布： WO2011/095052 WO 20110811
- 主分类号： C07F9/142
- IPC分类号： C07F9/142
摘要：
1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4), and preparation method thereof are provided. The preparation method comprises: reacting a pseudo ionone of formula (2) with sulfonium salt to prepare a epoxide of formula (9), and then reacting the epoxide of formula (9) with magnesium bromide to prepare a C-14 aldehyde of formula (3); condensing the C-14 aldehyde of formula (3) with tetra-alkyl methylene diphosphonate to obtain 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4). Furthermore, the preparation method of lycopene via 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4) is also provided. The present method has the advantages of short route, easily obtained raw materials, and low cost.
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