Systems and methods are disclosed for employing an equalization technique that improves equalizer input sensitivity and which reduces power consumption. In particular, an equalization architecture is described that includes a continuous-time linear equalizer and a decision feedback equalizer, each with offset cancellation that enables the equalizer to be used at high data rates. In addition, the equalization structure has a power-saving mode for bypassing the decision feedback equalizer. These offset cancellation and power-saving features are enabled and controlled using programmable logic on a programmable device.