Invention Grant
- Patent Title: Method of predicting responsiveness to autologous adoptive cell transfer therapy
- Patent Title (中): 预测自体过继细胞转移治疗反应的方法
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Application No.: US12679696Application Date: 2008-09-15
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Publication No.: US08541185B2Publication Date: 2013-09-24
- Inventor: Kfir Oved , Eran Eden , Martin Akerman , Roy Noy , Michal Besser , Yoram Reiter
- Applicant: Kfir Oved , Eran Eden , Martin Akerman , Roy Noy , Michal Besser , Yoram Reiter
- Applicant Address: IL Haifa IL Ramat-Gan
- Assignee: Technion Research & Development Foundation Limited,Tel HaShomer Medical Research Infrastructure and Services Ltd.
- Current Assignee: Technion Research & Development Foundation Limited,Tel HaShomer Medical Research Infrastructure and Services Ltd.
- Current Assignee Address: IL Haifa IL Ramat-Gan
- International Application: PCT/IL2008/001224 WO 20080915
- International Announcement: WO2009/040789 WO 20090402
- Main IPC: G01N33/574
- IPC: G01N33/574 ; C12Q1/02 ; C12N5/07
Abstract:
A method of determining responsiveness to cancer treatment is disclosed. The method comprises analyzing a frequency of tumor infiltrating lymphocytes (TILs) having a CD8+CD28−CD152− signature in a sample of the subject, wherein a frequency of TILs having the CD8+CD28−CD152− signature above a predetermined level is indicative of a positive responsiveness to cancer treatment. Other signatures reflecting responsiveness to cancer treatment are also disclosed. In addition, methods of treating cancer based on these signatures are also disclosed.
Public/Granted literature
- US20100310534A1 T CELL SUBPOPULATIONS CAPABLE OF TREATING CANCER Public/Granted day:2010-12-09
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