- 专利标题: Modified reconstituted basement membrane composition for assay system
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申请号: US12567996申请日: 2009-09-28
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公开(公告)号: US08541235B2公开(公告)日: 2013-09-24
- 发明人: Min Wu , Frank J. Mannuzza
- 申请人: Min Wu , Frank J. Mannuzza
- 申请人地址: US NY Corning
- 专利权人: Corning Incorporated
- 当前专利权人: Corning Incorporated
- 当前专利权人地址: US NY Corning
- 代理机构: Hoffmann & Baron, LLP
- 主分类号: C12N5/00
- IPC分类号: C12N5/00
摘要:
A modified reconstituted extracellular matrix composition is provided herein. The composition includes an extracellular matrix and at least one exogenous component selected from heparin, fibronectin and laminin. The composition may have a basic pH. Additionally, provided herein is a cell culturing system including a substrate and a coating thereon of the composition to assess potential stimulators and/or inhibitors for their effects on various cell cultures while increasing the signal dynamic range.