A device and methods are provided for calculating depth estimation for a digital imaging device are disclosed and claimed. In one embodiment, a method includes detecting a first image associated with a first focus parameter, detecting a second image associated with a second focus parameter, calculating a statistical representation of a region of interest in the first and second images, and determining a ratio for the region of interest based on the statistical representation. The method may further include determining one or more focus characteristics using a memory table based on the determined ratio for the region of interest, and calculating a focus depth for capture of image data based on the determined one or more focus characteristics associated with the memory table.