Invention Grant
US08546121B2 Variants of an alpha-amylase with improved production levels in fermentation processes
有权
在发酵过程中提高生产水平的α-淀粉酶的变体
- Patent Title: Variants of an alpha-amylase with improved production levels in fermentation processes
- Patent Title (中): 在发酵过程中提高生产水平的α-淀粉酶的变体
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Application No.: US12601759Application Date: 2008-05-29
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Publication No.: US08546121B2Publication Date: 2013-10-01
- Inventor: Wolfgang Aehle , Neelam S. Amin
- Applicant: Wolfgang Aehle , Neelam S. Amin
- Applicant Address: US CA Palo Alto
- Assignee: Danisco US Inc.
- Current Assignee: Danisco US Inc.
- Current Assignee Address: US CA Palo Alto
- Agency: Danisco US Inc.
- International Application: PCT/US2008/006787 WO 20080529
- International Announcement: WO2008/153815 WO 20081218
- Main IPC: C12N9/26
- IPC: C12N9/26

Abstract:
Variants of Bacillus sp. no. 707 alpha amylase are provided that are produced more efficiently and thus more economically. Higher fermentation yields are achieved through introducing amino acid variations that promote solubility of the variant in a fermentation broth. Increased solubility allows more enzyme to remain in solution after expression in a host cell. This in turn increases the efficiency with which the expressed variant enzyme can be recovered from the fermentation broth.
Public/Granted literature
- US20110027252A1 Variants of An Alpha-Amylase with Improved Production Levels in Fermentation Processes Public/Granted day:2011-02-03
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