发明授权
US08546440B2 Substituted bicyclic imidazole derivatives as gamma secretase modulators
有权
取代的双环咪唑衍生物作为γ分泌酶调节剂
- 专利标题： Substituted bicyclic imidazole derivatives as gamma secretase modulators
- 专利标题（中）： 取代的双环咪唑衍生物作为γ分泌酶调节剂
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申请号： US13133027申请日： 2009-12-16
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公开(公告)号： US08546440B2公开(公告)日： 2013-10-01
- 发明人: Henricus Jacobus Maria Gijsen , Gregor James MacDonald , François Paul Bischoff , Gary John Tresadern , Andrés Avelino Trabanco-Suárez , Sven Franciscus Anna Van Brandt , Didier Jean-Claude Berthelot
- 申请人： Henricus Jacobus Maria Gijsen , Gregor James MacDonald , François Paul Bischoff , Gary John Tresadern , Andrés Avelino Trabanco-Suárez , Sven Franciscus Anna Van Brandt , Didier Jean-Claude Berthelot
- 申请人地址： US NJ Titusville
- 专利权人： Janssen Pharmaceuticals, Inc.
- 当前专利权人： Janssen Pharmaceuticals, Inc.
- 当前专利权人地址： US NJ Titusville
- 代理商 Peter Herridge
- 优先权： EP08172202 20081218
- 国际申请： PCT/EP2009/067321 WO 20091216
- 国际公布： WO2010/070008 WO 20100624
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/506 ; A61K31/4439 ; A61K31/4196 ; A61K31/4188 ; C07D487/04
摘要：
The present invention is concerned with novel substituted bicyclic imidazole derivatives of Formula (I) wherein R0, R1, R3, R4, X, A1, A2, A3, A4, Y1, Y2 and Y3 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said novel compound as an active ingredient as well as the use of said compounds as a medicament.
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