An adaptable connection enclosure (ACE) is disclosed. The ACE can employ a number of different connector blocks thereby enhancing versatility to address a myriad of different connection scenarios. In aspects, the ACE can support coax, coax/fiber, coax/CAT5, fiber/CAT5, fiber or CAT5 connector blocks without altering the ACE housing. In accordance therewith, adapter plates can be employed to effect the interchangeability.