A vehicle and method of operation having a first door, a second door, an inflatable door seal assembly and an inflator assembly. The first door has a first opening side and a first seal mount extending along the first opening side. The second door has a second opening side adjacent to the first opening side to define a gap and a second seal mount extending along the second opening side. The door seal assembly has a first seal assembly mounted to one of the first or second seal mounts, the first seal assembly inflatable to extend into the gap toward the other of the seal mounts when the first and second door are closed and deflatable to retract from the gap. The inflator assembly pumps a fluid into the seal assembly to inflate the seal assembly and pumps the fluid out to deflate the seal assembly.