发明授权
- 专利标题: Method of detecting articular cartilage degeneration or damage
- 专利标题(中): 检测关节软骨退化或损伤的方法
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申请号: US12525869申请日: 2008-02-05
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公开(公告)号: US08557536B2公开(公告)日: 2013-10-15
- 发明人: Shigeyuki Wakitani , Masashi Nawata , Kyosuke Miyazaki , Hiroyuki Masuda , Hiroshi Fujita , Yasuhiro Kurahashi
- 申请人: Shigeyuki Wakitani , Masashi Nawata , Kyosuke Miyazaki , Hiroyuki Masuda , Hiroshi Fujita , Yasuhiro Kurahashi
- 申请人地址: JP Tokyo
- 专利权人: Seikagaku Corporation
- 当前专利权人: Seikagaku Corporation
- 当前专利权人地址: JP Tokyo
- 代理机构: Kratz, Quintos & Hanson, LLP
- 优先权: JP2007-025731 20070205
- 国际申请: PCT/JP2008/051839 WO 20080205
- 国际公布: WO2008/096738 WO 20080814
- 主分类号: C12Q1/34
- IPC分类号: C12Q1/34
摘要:
An object of the present invention is to provide a detection method capable of detecting articular cartilage degeneration or damage in which the abnormality cannot be detected in a radiograph in a simple method and with high accuracy, a method of evaluating the rate of progression of articular cartilage degeneration or damage, and the like.The present invention as a means for achieving the object provides a method of detecting articular cartilage degeneration or damage which cannot be detected in a radiograph, by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.Further, the present invention provides a method of evaluating the rate of progression of articular cartilage degeneration or damage by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.