发明授权
- 专利标题： Method of detecting articular cartilage degeneration or damage
- 专利标题（中）： 检测关节软骨退化或损伤的方法
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申请号： US12525869申请日： 2008-02-05
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公开(公告)号： US08557536B2公开(公告)日： 2013-10-15
- 发明人: Shigeyuki Wakitani , Masashi Nawata , Kyosuke Miyazaki , Hiroyuki Masuda , Hiroshi Fujita , Yasuhiro Kurahashi
- 申请人： Shigeyuki Wakitani , Masashi Nawata , Kyosuke Miyazaki , Hiroyuki Masuda , Hiroshi Fujita , Yasuhiro Kurahashi
- 申请人地址： JP Tokyo
- 专利权人： Seikagaku Corporation
- 当前专利权人： Seikagaku Corporation
- 当前专利权人地址： JP Tokyo
- 代理机构： Kratz, Quintos & Hanson, LLP
- 优先权： JP2007-025731 20070205
- 国际申请： PCT/JP2008/051839 WO 20080205
- 国际公布： WO2008/096738 WO 20080814
- 主分类号： C12Q1/34
- IPC分类号： C12Q1/34
摘要：
An object of the present invention is to provide a detection method capable of detecting articular cartilage degeneration or damage in which the abnormality cannot be detected in a radiograph in a simple method and with high accuracy, a method of evaluating the rate of progression of articular cartilage degeneration or damage, and the like.The present invention as a means for achieving the object provides a method of detecting articular cartilage degeneration or damage which cannot be detected in a radiograph, by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.Further, the present invention provides a method of evaluating the rate of progression of articular cartilage degeneration or damage by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.