Invention Grant
US08557812B2 Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof
有权
抗细胞凋亡BCL-2家族成员的小分子抑制剂及其用途
- Patent Title: Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof
- Patent Title (中): 抗细胞凋亡BCL-2家族成员的小分子抑制剂及其用途
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Application No.: US11209998Application Date: 2005-08-22
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Publication No.: US08557812B2Publication Date: 2013-10-15
- Inventor: Shaomeng Wang , Guoping Wang , Guozhi Tang , Renxiao Wang , Zaneta Nikolovska-Coleska , Dajun Yang , Liang Xu
- Applicant: Shaomeng Wang , Guoping Wang , Guozhi Tang , Renxiao Wang , Zaneta Nikolovska-Coleska , Dajun Yang , Liang Xu
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones SC
- Main IPC: C07D401/02
- IPC: C07D401/02 ; A61K31/47
Abstract:
The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
Public/Granted literature
- US20060084647A1 Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof Public/Granted day:2006-04-20
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