发明授权
US08557992B2 Heterocyclic fused phenanthrolinone M1 receptor positive allosteric modulators
有权
杂环稠合菲咯啉酮M1受体阳性变构调节剂
- 专利标题： Heterocyclic fused phenanthrolinone M1 receptor positive allosteric modulators
- 专利标题（中）： 杂环稠合菲咯啉酮M1受体阳性变构调节剂
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申请号： US13703983申请日： 2011-06-10
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公开(公告)号： US08557992B2公开(公告)日： 2013-10-15
- 发明人: Scott D. Kuduk , Jason W. Skudlarek
- 申请人： Scott D. Kuduk , Jason W. Skudlarek
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Sylvia A. Ayler; Gerard M. Devlin
- 国际申请： PCT/US2011/039893 WO 20110610
- 国际公布： WO2011/159553 WO 20111222
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; C07D221/22
摘要：
The present invention is directed to heterocyclic fused phenanthrolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.