Invention Grant
- Patent Title: Pyrazoloquinoline derivatives
- Patent Title (中): 吡唑并喹啉衍生物
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Application No.: US13644745Application Date: 2012-10-04
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Publication No.: US08563565B2Publication Date: 2013-10-22
- Inventor: Yoshihiko Norimine , Kunitoshi Takeda , Koji Hagiwara , Yuichi Suzuki , Yuki Ishihara , Nobuaki Sato
- Applicant: Eisai R&D Management Co., Ltd.
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A01N43/58 ; A01N43/60 ; A61K31/505 ; A61K31/535 ; C07D413/00 ; C07D487/00 ; C07D471/00 ; C07D403/00
Abstract:
A compound and/or pharmacologically acceptable salt thereof represented by the formula (I) has PDE9 inhibitory action, so that the intracerebral cGMP concentration is anticipated to be elevated. The PDE9 inhibitory action and the increase in cGMP lead to the improvement of learning and memory behaviors, and the compound (I) has a potential use of a therapeutic agent for cognitive dysfunctions in Alzheimer's disease. wherein R1 is a hydrogen atom; R2 is an aromatic ring group, etc.; R3 is a hydrogen atom, etc; R4 is a hydrogen atom; R5 is an oxepanyl group, etc.; R6 is a hydrogen atom.
Public/Granted literature
- US20130143907A1 PYRAZOLOQUINOLINE DERIVATIVES Public/Granted day:2013-06-06
Information query
IPC分类:
