Integrated circuits may include memory interface circuitry operable to communicate with system memory. The memory interface circuitry may receive data and data strobe signals from system memory during read operations. The memory interface circuitry may include de-skew circuitry and dynamic variation compensation circuitry. The de-skew circuitry may be configured during calibration procedures to reduce skew between the data and data strobe signals. The dynamic variation compensation circuitry may be used in real time to compensate for variations in operating conditions. The dynamic variation compensation circuitry may include a phase generation circuit operable to generate data strobe signals having different phases, an edge detection circuit operable to detect leading/trailing edge failures, a control circuit operable to control a counter, and an adjustable delay circuit that is controlled by the counter and that is operable to properly position the data signal with respect to its corresponding data strobe signal.