发明授权
- 专利标题： High concentration antibody-containing liquid formulation
- 专利标题（中）： 含高浓度抗体的液体制剂
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申请号： US12810938申请日： 2008-12-26
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公开(公告)号： US08568720B2公开(公告)日： 2013-10-29
- 发明人: Toshiyuki Morichika , Daisuke Kameoka , Yoshimi Imaeda , Terutoshi Maeda , Oliver Boris Stauch
- 申请人： Toshiyuki Morichika , Daisuke Kameoka , Yoshimi Imaeda , Terutoshi Maeda , Oliver Boris Stauch
- 申请人地址： JP Tokyo CH Basel
- 专利权人： Chugai Seiyaku Kabushiki Kaisha,F. Hoffmann - La Roche AG
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha,F. Hoffmann - La Roche AG
- 当前专利权人地址： JP Tokyo CH Basel
- 代理机构： Browdy and Neimark, P.L.L.C.
- 优先权： JP2007-336310 20071227
- 国际申请： PCT/JP2008/073798 WO 20081226
- 国际公布： WO2009/084659 WO 20090709
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395 ; A61K38/00
摘要：
The problem to be solved is to provide an antibody-containing formulation which is stable and suited for subcutaneous administration, wherein dimerization and deamidation is prevented during long-term storage. The present application is directed to a stable antibody-containing liquid formulation characterized by containing arginine and methionine.
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